Center of Psychiatry and Neuroscience
Center of Psychiatry and Neuroscience
I have over 35 years’ experience in research on preclinical, animal studies of central nervous system (CNS) networks that are involved in pain processing. Most of my work has been devoted to the elucidation the functional architecture of endogenous CNS mechanisms of pain modulation, by employing combined anatomical, electrophysiological and behavioral in vivo approaches, with special emphasis on top-down, brainstem, hypothalamic and corticofugal controls. I have managed the work of many people in different laboratories in France, including several PhD students, postdoctoral fellows, master students and technicians. A number of my past projects have been funded by grants that brought together applicants from France and abroad, including Grants for collaborative projects with labs in the USA, Mexico and Chile. I have successfully driven research projects which have resulted in more than 70 manuscripts published in peer-reviewed journals, 30 Book chapters and 90 abstracts.
– Identification of central networks involved in Diffuse Noxious Inhibitory Controls.
– Discovery of a novel brainstem nucleus that plays a key role in the integration of pain signals : the Subnucleus Reticularis Dorsalis.
– Development of high-resolution neuroanatomical tracing and computer-assisted reconstruction imaging techniques for the study of pain networks.
– Discovery of a thalamic relay of noxious inputs from the whole body surface to the neocortex: the ventromedial thalamic nucleus.
– Development of juxtacellular and multiunit-multisite electrophysiological techniques for the study of thalamo-cortical networks.
– Characterisation of the functional architecture of thalamo-cortical loops involved in the discrimination of tactile and noxious inputs.
– Demonstration of a selective corticofugal modulation of trigeminovascular nociceptive inputs involved in migraine headache processing.
– Deciphering hypothalamic networks involved in dysfunctional mechanisms at the origin of trigeminal autonomic cephalalgias.
POSITIONS AND HONORS
Positions and Employment
1978-1981 Lecturer, Department of Pharmacology, Faculty of Medicine, University of Chile, Santiago.
1981-1983 Fellow from the French Ministry of Education 1983-1988 Doctoral-postdoctoral Fellows from the pharmaceutical industry (Sandoz, Houdé)
1988-1995 Researcher (tenure), French National Center of Scientific Research
1995-2001 Director of Research, CNRS (tenure), PI at Pain Unit INSERM U.161
2001-2006 PI and co-founder of Pain Unit INSERM E-216, Clermont- Ferrand
2006-2007 Vice-Director, Biomedical Teaching Institute (IFSBM), Faculty of Medicine, Paris University
2007-2010 PI at INSERM U.894, Pitié Salpetriere Hospital, Paris
2011- PI at Center of Psychiatry & Neurosciences, INSERM U.894, Sainte-Anne Hospital, Paris. Head of the team “Pain, stress & neuroinflammation”
1978 Outstanding Young Faculty Award, Faculty of Dentistry, University of Chile, Santiago
1986 Award for best, summa cum laude in DSc thesis dissertation, University of Paris, France
1987- Member, International Association for the Study of Pain (IASP)
1987- Member, French Chapter of IASP (SFETD)
1991- Member, Society for Neuroscience, USA
1993- Member, European Pain Federation (EFIC)
1996-2000 Member, Research Committee, IASP
2000- Editorial Board, Archives of Oral Biology
2002-2006 Member, Membership Committee, IASP,
2005 Coordinator, Chapter Anatomy and Physiology of Pain, Core Curriculum for Professional Education in Pain, IASP
2008- Editorial Board, Faculty 1000, Anesthesiology & Pain Management
2010-2014 Member, Council of French Chapter of IASP
2011- Section Editor, European Journal of Pain
2009- French Councilor, EFIC
2011-2014 Vice-Chair, EFIC Committee on Scientific Research
2014-2016 Member, Executive Board, Treasurer, SFETD (CNRS); PI at Pain Unit INSERM U.161, Paris, France
2014- Chair, EFIC Committee on Scientific Research
– Teaching in Pain neuroanatomy, neurophysiology, pathophysiology and neuropharmacology in Medical and Faculty of Sciences (graduate and post-graduate programs) in France since more than 30 years. Training of undergraduate, graduate students and post-doctoral research fellows. Supervisory Committees, current external examiner for PhD students in Europe and Canada.
– Study sections member and scientific expertise reports for National, European, Canadian and USA Grants.
– Ad-hoc referee for several Neuroscience Journals.